Effects of methionine-induced hyperhomocysteinemia on protein C,antithrombin-Ⅲ and von willebrand factor / 中国病理生理杂志

ABSTRACT

AIM: To observe the effects of methionine-induced hyperhomocysteinemia on protein C(PC), antithrombin-Ⅲ (AT-Ⅲ) and von willebrand factor (vWF). METHODS:Eighteen New Zealand rabbits were randomized as methionine group (group M,n=9) and control(group C,n=9), which were fed with methionine-rich diet(600 mg/d) and regular diet respectively for sixteen weeks.By the end of sixteen weeks,the serum biochemistry and PC,AT-Ⅲ and vWF in plasma were determined and vWF expression of endothelial cells of aorta were examined.RESULTS:In group M, the levels of methionine(29.97?5.34 ?mol/L) and homocysteine(13.30?2.19 ?mol/L) in serum were signifficantly higher than those(14.48?1.97 ?mol/L and 5.36?1.19 ?mol/L, respectively,P