Effects of propofol and enflurane on intrapulmonary shunt and plasma levels of endothelin and nitric oxide during one lung ventilation / 中华麻醉学杂志

ABSTRACT

Objective To observe the effects of propofol and enflurane on intrapulmonary shunt and the changes of plasma endothelin ( ET ) and nitric oxide ( NO ) in the pulmonary artery and vein during one lung ventilation ( OLV ) Methods Thirty patients undergoing elective thoracotomy with OLV were randomly allocated to receiving enflurane at an inspired concentration of 1 8%(enflurane group) or an intravenous infusion of propofol at rate of 6 mg?kg -1 ?h -1 The arterial and mixed venous blood gas analysis and the plasma concentrations of ET and NO in the pulmonary artery and vein were measured 30 min after beginning of two lung ventilation ( TLV ) , 30 min and 60 min after of beginning OLV Results In both groups , the venous admixture percentage(Qs/Qt) increased significantly 30 and 60 min after beginning of OLV compared with that 30 min after beginning of TLV (P0 05) ET concentration in the pulmonary vein increased significantly following OLV in propofol group (P0 05) Conclusion Propofol at clinical dosage does not inhibit hypoxic pulmonary vasoconstriction The atelectasis and hypoxic stimulus during OLV can make pulmonary endothelium release ET or inhibit pulmonary elimination of ET Enflurane can suppress the above process