The effects of insulin like growth factorⅠ on the intestinal adaptation in growth hormone-treated rats / 中国普通外科杂志

ABSTRACT

Objective To understand the effect of insulin-like growth factorⅠ (IGFⅠ) on the adaptation of the small intestine in growth hormone (GH)-treated rats. Method 20 SD rats were randomized into GH group and STD group. Parenterally fed, short bowel rat models were established. The morphological changes of the intestinal mucosal epithelia were examined, serum GH, IGFⅠ concentrations were determined by RIA method. The local intestinal IGFⅠ mRNA was evaluated by Northern blot method. Result At the end of the study, mucosal thickness, villous height, crypt depth in GH group (471?16, 299?17, 161?20 ?m respectively) increased significantly compared to that in STD group (374?13, 212?19, 96?9 ?m respectively, all P