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Role of caspase-3 dependent hepatocyte apoptosis in liver ischemia-reperfusion injury in cirrhotic rats / 中国病理生理杂志
Chinese Journal of Pathophysiology ; (12)1989.
Artículo en Chino | WPRIM | ID: wpr-517807
ABSTRACT

AIM:

To investigate whether hepatocyte apoptosis is contributed to liver ischemia-reperfusion (I/R) injury and the relationship between liver caspase-3 activity and hepatocyte apoptosis in cirrhotic rats.

METHODS:

Liver ischemia-reperfusion is induced by Pringle maneuver. The cirrhotic rats were randomized into two groups Group A simple hepatic blood inflow occlusion (HBIO); Group B HBIO + inhibitor, before HBIO, ZVAD-fmk 15 mg/kg was injected via dorsal penis vein; Group C healthy rat, simple HBIO. The ischemia time was 30 min in these groups. Serum aspartate aminotransferase(AST), liver caspase-3 activity, and apoptotic hepatocytes were examined in the three groups.

RESULTS:

After 6 h of reperfusion, the liver caspase-3 activity was markedly elevated and reached its peak, which was statistically higher than that of before I/R [(18.1?1.8 ) ?mol?h -1 ?g -1 (tissue) vs (6.6?2.0) ?mol?h -1 ?g -1 (tissue), P

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Ensayo Clínico Controlado Idioma: Chino Revista: Chinese Journal of Pathophysiology Año: 1989 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Ensayo Clínico Controlado Idioma: Chino Revista: Chinese Journal of Pathophysiology Año: 1989 Tipo del documento: Artículo