Distortion Product Otoacoustic Emissions in Age-related Hearing Loss of C57 and BALB/c Inbred Mouse Strains / 听力学及言语疾病杂志

ABSTRACT

Objective To assess the dynamic age-related hearing loss of inbred mouse C57 and BALB/c strains via distortion product otoacoustic emissions(DPOAE). Methods DPOAE levels were evaluated in C57 and BALB/c of 20,30,60,90,120,150,180 days old respectively,with the conditions that two pure tones,which stimulated the DPOAE,were at frequencies(f 1,f 2,f 1/f 2=1.22)and levels(L 1=70 dB SPL,L 2=65 dB SPL).Results DPOAE levels of C57 and BALB/c gradually decreased with age.From 60 days old,DPOAE levels of the two strains were dramatically decreased at 4.0,6.0,8.0 kHz( P