Assay of Concentration of Isoniazid in Plasma With HPLC / 中国药房
China Pharmacy
;
(12)1991.
Artículo
en Chino
| WPRIM
| ID: wpr-518791
ABSTRACT
OBJECTIVE:
A HPLC method has been developed to determine the concentration of isoniazid in plasma.METH_ODSThe Eclipse XDB-C18 column was used as fix phase and acetonitrile-0.05mol/L ammonium dihydrogen phosphate as mo_bile phase,detection wavelength was 280nm.The plasma sample was injected directly for determination after being deproteinized with 10% trichloroacetic acid and reacted with cinnamaldehyde and abstracted with ether.RESULTS:
Good linear relationship was shown from 0.10 to 12.0?g/ml and the averge recovery of isoniazid was 95%~105%.CONCLUSION:
The method is rapid,sensitive and is rarely interfered so it can be used in study of pharmacokinetics of isoniazid.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacy
Año:
1991
Tipo del documento:
Artículo
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