Preparation and Quality Contorl of Econazole Nitrate Ear-drops / 中国药房
China Pharmacy
;
(12)1991.
Artículo
en Chino
| WPRIM
| ID: wpr-519048
ABSTRACT
OBJECTIVE:
To establish the preparation process and method of quality control of econazole nitrate ear-drops.METHODS:
With mixture of glycerin and 75% alcohol as solvent,econazole nitrate ear-drops was prepared and the content of econazole was determined by ultraviolet spectrophotometry.The stability,irritation and in vitro antimicrobial tests were carried out.RESULTS:
There was a good linearity of calibration curve of econazole in range of 200~600?g/ml,r=0.9 999,the average recovery was 100.76%,RSD=0.82%(n=5).The in vitro antimycotic MICs of econazole nitrate in ear-drops were 2?g/ml and 4?g/ml against standard and clinically isolated strains of Candida albicans respectively.CONCLUSION:
The ear-drops is simple in preparation,effective in antimycotic action,good in stability and slight in irritability,and the method of quality control is simple,rapid and accurate.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacy
Año:
1991
Tipo del documento:
Artículo
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