Effect of Ba~(2+) concentration on L-type Ca~(2+) channel in hypothalamic neurons / 中国病理生理杂志

ABSTRACT

AIM: To investigate the effect of Ba 2+ concentration on L-type of Ca 2+ channel in hypothalamic neurons.METHODS: The cell acute isolation technique and cell-attached patch-clamp technique were used. RESULTS : The slope conductance of L-type Ca 2+ channel were 28.6 pS (110 mmol/L) and 19.1 pS (10 mmol/L), and the open probability (NP 0) obviously different with different Ba 2+ concentration as carrier. CONCLUSION: Ba 2+ concentration had the obvious effect on the L-type Ca 2+ channel.