Determination of the Contents in Compound Furacilin Nasal Drops by RP-HPLC / 中国药房

ABSTRACT

OBJECTIVE:A RP-HPLC method to determine the contents of furacilin and ephedrine hydrochloride in compound furacilin nasal drops was established METHODS:Chromatographic detection was performed with a mixture of methanol-water-triethylamine-acetic acid(12∶88∶0 2∶1) as mobile phase and Kromasil C18(4 6mm?250mm,5?m) as separate column Chloramphenicol was selected as internal standard and the detection wavelength was 254nm RESULTS:The ingredients of compound furacilin nasal drops and internal standard were well separated within 18min Good linearities and recoveries for furacilin and ephedrine hydrochloride were obtained in their assay ranges CONCLUSION:The RP-HPLC method was found to be simple,accurate and suitable for the quality control of compound furacilin nasal drops