Protective Effect of Ligustrazin on the Mitochondrial Damage of Myocardium in Ischemiareperfusion Rats / 中国药房
China Pharmacy
; (12)2001.
Article
en Zh
| WPRIM
| ID: wpr-519324
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WPRO
ABSTRACT
OBJECTIVE:To observe the effect of ligustrazin on the mitochondrial damage of myocardium in ischemia-reperfusion rats and the mechanism involved METHODS:Rat model of myocardial ischemia-reperfusion injury was established by coronary artery ligation and the activities of Ca2+-ATPase,Ca2+?Mg2+-ATPase,succinic dehydrogenase(SDH),cytochrome oxidase(CCO),SOD,GSH-PX and contents of phospholipid(PL),MDA,Cyt aa3 and Cyt C in the myocardial mitochondria were observed RESULTS:As compared with ischemia-reperfusion group(IR),IR+L(ligustrazin)group showed significant increase in the activities of Ca2+-ATPase,Ca2+?Mg2+-ATPase,SDH,CCO,SOD and GSH-PX(P
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Zh
Revista:
China Pharmacy
Año:
2001
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Article