Determination of the Level of Sodium Ferulate in Plasma by HPLC / 中国药房

ABSTRACT

OBJECTIVE:A HPLC method was established for determination of the level of sodium ferulate in plasma.ME_THODSA C18 radial compression column was used with a mobile phase of CH3OH∶H2O∶H3PO4(250∶250∶0.2).The detecing wavelength was 254nm.RESULTS:The linear range was 1.2～24?g/ml(r=0.9 993).The average recovery was(98.8?0.6)%.The RSDs of within-day and between-day were less than 10%.CONCLUSION:This method provides an accurate and sensitive way in detecting plasma concentration of sodium ferulate.