Expression of genes encoding gap junction protein in normal human nasopharyngeal epithelial tissue / 中国病理生理杂志

ABSTRACT

AIM: To examine the expression of gap junction protein family genes, including thirteen independent genes, in normal human nasophryngeal epithelial tissue and to conjecture the possible roles of gap junction proteins in nasopharyngeal carcinoma. METHODS: With synthesized primers, the expression of thirteen genes encoding different gap junction proteins in human normal nasopharyngeal epithelial tissue were detected by RT-PCR. RESULTS: In 18 samples of normal human nasopharyngeal epithelial tissue, 16 of them were found the expression of Cx 30, 31 1, 17 of them were found the expression of Cx 37 and Cx 43, and Cx 40 expression were detected in 15 samples. Also the expression of Cx 26, 31, 32, 36, 45, 46, 46 6, 50 were detected respectively in 10, 11, 9, 1, 9, 0, 1,3 samples of the 18 cases. CONCLUSION: In normal human nasopharyngeal tissue, Cx 30, 31, 31 1,37, 40, 43 might be the key gap junction proteins.