Determination of the Contents of Three Ingredients in Compound Chloramphenicol Tincture by Multi?wavelength Coefficient Spectrophotometry / 中国药房

ABSTRACT

OBJECTIVE:To establish a method for simultaneously determining chloramphenicol,salicylic acid and metroni_ dazole in compound chloramphenicol tincture with no need for separation.METHODS:The concentrations of three main in?gredients were determined by multiwavelength coefficient spectrophotometry,the detecting wavelengths being277.5,297.0and317.0nm respectively.RESULTS:The average recoveries of chloramphenicol,salicylic acid and metronidazole were(100.22?0.74)%,(99.25?1.54)%and(99.79?1.92)%respectively.CONCLUSION:This method is simple,rapid and accurate.It is suitable for the determination of multicomonent preparation in hospital routine analysis.