Relationship Between Resistant Plasmids and Drug-resistance in Neisseria gonorrhoeae / 中华皮肤科杂志

ABSTRACT

Objective To explore the role of plasmids in inducing drug-resistance in Neisseria gonor-rhoeae.Methods The change of drug-susceptibility in Neisseria gonorrhoeae was compared before and after experiments of resistant plasmids conjugation,transformation and deleting.Results The drug-resistance was transferred from resistant strains to sensitive strains through the conjugation and transformation of resistant plasmids,while the drug susceptibility could be recovered through deleting such plasmids from resistant strains.Conclusion The plasmids play an important role in the development of drug-resistance in Neisseria gonorrhoeae.