The Levels of Plasma Insulin and Erythrocyte Insulin Receptors in Children with Acanthosis Nigricans Associated with Obesity / 中华皮肤科杂志

ABSTRACT

Objective To investigate the role of insulin resistance in the pathogenesis of childhood benign acanthosis nigricans with obesity and the relationship between insulin resistance and insulin receptors.Methods Fasting plasma insulin and the amount of erythrocyte insulin receptors were determined among17children with benign acanthosis nigricans with obesity(CBANO),with16cases of simple adiposis and15healthy children as controls.Results The levels of plasma insulin were higher in CBANO than those in sim-ple adiposis and healthy controls;however,the amount of erythrocyte insulin receptors was lower in CBANO than that in simple adiposis and healthy controls.Conclusion Insulin resistance caused by diminished in-sulin receptors may play an important role in pathogenesis of CBANO.