Effects of hydrogen peroxide on sodium current in acutely isolated rat hippocampal CA1 neurons / 中国病理生理杂志

ABSTRACT

AIM and METHODS: The effects of hydrogen peroxide on Na+ currents were studied in freshly dissociated rat hippocampal CA1 neurons using the whole-cell patch-clamp techinique. RESULTS: 2貶 2O 2 caused a dose-dependent and voltage-dependent increase in the voltage-activated Na+ currents. The amplitudes of Na+ currents were increased (48.0?4.2)% and (88. 2?5. 1)% (n=10) by H 2O 2 at 10 ?mol/L and 100 ?mol/L, respectively. ②H 2O 2 (10 ?mol/L) did not affect the activation process, but changed the inactivation process significantly. Before and after application of 10 ?mol/L of H 2O 2, the half-inactivation voltage was (-64.58?1.22)mV and (-53.55?0.94)mV (n=10, P