Polymorphism of Haptoglobin in Patients with Premature Rupture of Membrane
Yonsei Medical Journal
; : 132-136, 2009.
Article
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| WPRIM
| ID: wpr-52282
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: To investigate whether allelic polymorphism of haptoglobin (Hp) is associated with premature rupture of membrane (PROM), the Hp phenotypes of pregnant women with PROM were analyzed. PATIENTS AND METHODS: The Hp phenotypes of 221 pregnant Korean women (187 control and 34 PROM patients) were determined by benzidine/hydrogen peroxide staining, following native polyacrylamide gel electrophoresis of hemoglobin-mixed sera. The Hp allele frequencies were calculated from the data of Hp phenotypes, and overall association with PROM was evaluated using Pearson Chi-Square test. RESULTS: The polymorphic distribution of the patients cohort who underwent a normal delivery (control group) was similar to that of healthy Koreans. In contrast, however, patients with PROM showed significantly higher occurrence of the Hp 1-1 phenotype than control group (23.5% vs 8.0%). Hp 2-2 phenotype was lower in PROM cohort (38.2%) than in the control group (48.7%). The Hp1 allele frequency in PROM group was significantly higher than that in the control group (0.426 vs 0.297, p = 0.034) with odds ratio of 1.762 (95% CI: 1.038 - 2.991). CONCLUSION: These findings suggest that pregnant Korean women who possess Hp1 allele (expressed as Hp 1-1 phenotype) have higher incidence of PROM than women with Hp2 allele (expressed as Hp 2-2 phenotype). This is the first study that evaluated the significance of Hp polymorphism with respect to the development of PROM.
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Índice:
WPRIM
Asunto principal:
Fenotipo
/
Polimorfismo Genético
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Rotura Prematura de Membranas Fetales
/
Haptoglobinas
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Incidencia
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Predisposición Genética a la Enfermedad
/
Pueblo Asiatico
/
Frecuencia de los Genes
/
Corea (Geográfico)
Tipo de estudio:
Incidence_studies
/
Prognostic_studies
Límite:
Adult
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Female
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Humans
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Newborn
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Pregnancy
País/Región como asunto:
Asia
Idioma:
En
Revista:
Yonsei Medical Journal
Año:
2009
Tipo del documento:
Article