Relationship Between Expression of MDR_1 Gene in Cochlea Lateral Wall and Accumulation of Adriamycin in Endolymph of Guinea Pig / 听力学及言语疾病杂志
Journal of Audiology and Speech Pathology
;
(6)1998.
Artículo
en Chino
| WPRIM
| ID: wpr-522850
ABSTRACT
Objective To study the relationship between the expression of MDR 1 gene in cochlea lateral wall and the accumulation of adriamycin in endolymph of guinea pig.Methods Twenty four white guinea pigs with red eyes were randomly chosen,and administered an intravenous injection of 30 mg/kg adriamycin or N.S.The animals were sacrificed 24 hours later,the cochlea lateral wall was then immediately removed after the endolymph was drawn by the siphon from the basal turn of cochlea. The expression of the MDR 1 mRNA in cochlea lateral wall of guinea pigs were observed by RT-PCR.The ADM concentration in endolymph was measured by high performance liquid chromatography.Results The accumulation of adriamycin in endolymph negatively correlated with the expression of MDR 1 gene in cochlea lateral wall(r s=-0.901, P
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of Audiology and Speech Pathology
Año:
1998
Tipo del documento:
Artículo
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