The Effect of VEGF on the Expression of Fas and FasL in Ischemic Brain Tissues / 中国医师杂志
Journal of Chinese Physician
; (12)2001.
Article
en Zh
| WPRIM
| ID: wpr-523430
Biblioteca responsable:
WPRO
ABSTRACT
Objective To explore the mechanism of VEGF treating cerebral ischemia. Methods A rat model of middle cerebral artery occlusion (MCAO) was set up by nylon suture embolization. The naked plasmid DNA encoding vascular endothelial growth factor(pUCCAGGS/hVEGF 165 ) was directly injected through skull into the ischemic areas of brain. After seven days the rats were killed. RT-PCR was used to measure the expression of VEGF mRNA in the brain tissues, and immunohistochemistry was appllied to detect the expression of VEGF, Fas and Fas L in the brain tissues. Results Compared with control group, VEGF expression significantly increased in the therapeutic group(P
Texto completo:
1
Índice:
WPRIM
Tipo de estudio:
Prognostic_studies
Idioma:
Zh
Revista:
Journal of Chinese Physician
Año:
2001
Tipo del documento:
Article