Your browser doesn't support javascript.
loading
Changes in the expression of Bcl-2 and Fas in HL-60 cells treated with cyclosporine A / 中国病理生理杂志
Chinese Journal of Pathophysiology ; (12)2000.
Artículo en Chino | WPRIM | ID: wpr-523683
ABSTRACT

AIM:

To investigate the changes of the expression of Bcl-2 and Fas protein and the apoptosis in HL-60 cells induced by cyclosporine A.

METHODS:

The expression of Bcl-2 and Fas protein and apoptosis in (HL-60) cells were measured by immunohistochemistry analysis and flow cytometric analysis.

RESULTS:

There was strong expression of Bcl-2 in HL-60 cells, treatment with cyclosporine A (CsA) for 8-10 h down-regulated the expression of Bcl-2. Fas protein expression in HL-60 cells was very low, CsA induced apoptosis of HL-60 cells, but didn't induce Fas protein expression.

CONCLUSION:

CsA induces apoptosis in HL-60 cells by down-regulating Bcl-2 expression. [

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Journal of Pathophysiology Año: 2000 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Journal of Pathophysiology Año: 2000 Tipo del documento: Artículo