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Effects of inhibition of Kupffer cell and splenectomy on thioacetamide-induced hepatic injury / 中国病理生理杂志
Chinese Journal of Pathophysiology ; (12)2000.
Artículo en Chino | WPRIM | ID: wpr-523685
ABSTRACT

AIM:

To examine the effects of inhibition of Kupffer cell and splenectomy on intestinal endotoxemia and hepatic injury.

METHODS:

The hepatic injury model was established by treatment with thioacetamide (TAA). At the same time, inhibition of Kupffer cells by intravenous GdCl_3 and splenectomy were performed. Serum alanine aminotransferase (ALT), TNF-?, endotoxin content and phagocytic index were observed.

RESULTS:

In the TAA+GdCl_3 group, and TAA+splenectomy group, the endotoxin content was significently higher than that in normal and TAA group (P

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Journal of Pathophysiology Año: 2000 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Journal of Pathophysiology Año: 2000 Tipo del documento: Artículo