Study on Dissolution of Ibuprofen and Paracetamol in Soft Capsules / 中国药房
China Pharmacy
;
(12)1991.
Artículo
en Chino
| WPRIM
| ID: wpr-524220
ABSTRACT
OBJECTIVE:
To determine the dissolution of ibuprofen and paracetamol in soft capsules.METHODS:
Phos?phate buffer(pH=7.2)was taken as a solvent with the rotating speed set at75/min,and sample taken time was45minutes.The dissolution degree of ibuprofen and paracetamol in soft capsules were determined by a RP-HPLC method.The chro?matographic column was CN column;the mobile phase was phosphate buffer(pH=6.6)-methanol(60∶40)with a flow rate of1.0ml/min,the detection wavelength at223nm and the column temperature at30℃.RESULTS:
The linear calibration curves were obtained with a range of0.17~100.14?g/ml for paracetamol(r=0.9999,n=9)and0.21~124.86?g/ml for ibuprofen(r=0.9999,n=9)respectively;the average recoveries of the two compounds were99.62%(RSD=0.36%)and99.79%(RSD=0.49%)respectively.CONCLUSION:
The determination method is simple,rapid,accurate and reliable,which can be applied to measure the dissolution content of ibuprofen and paracetamol in soft capsules satisfactorily.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacy
Año:
1991
Tipo del documento:
Artículo
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