Study on the neonatal outcomes and congenital malformations in children born after in-vitro fertilization / 中华围产医学杂志

ABSTRACT

Objective To evaluate the neonatal outcomes and the prevalence of congenital malformations in children born after in-vitro fertilization(IVF). Methods IVF children (211 cases) born of 156 mothers from July 1994 to October 2003 and 218 controls were studied. Those controls were randomly chosen from the same hospital matched for the time and season of birth and maternal age. Results The incidence of multi-gestation (37.2% vs 2.3%, OR =24.62, 95% CI 9.1~72), preterm birth (37.2% vs 8.5%, OR =6.41, 95% CI 3.5~12.0), cesarean section (97.0% vs 71.8%, OR =14.9,95% CI5.0~49.5), pregnancy-induced hypetension (22.4% vs 10.8%, OR = 2.39, 95% CI1.3~4.9), threatened abortion (4.5% vs 0%, OR =3.11,95% CI2.0~4.8) were significantly higher in the IVF group, but the prevalcnce of fetal distress (14.6% vs 4.5%) was lower comparing with control group( P