Lymphangiogenesis in Breast Cancer Correlates with Matrix Stiffness on Shear-Wave Elastography
Yonsei Medical Journal
;
: 599-605, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-52541
ABSTRACT
PURPOSE:
To correlate tumor stiffness and lymphangiogenesis in breast cancer and to find its clinical implications. MATERIALS ANDMETHODS:
A total of 140 breast cancer patients were evaluated. Tumor stiffness was quantitatively measured by shear-wave elastography in preoperative ultrasound examination, calculated as mean elasticity value (kPa). Slides of resected breast cancer specimens were reviewed for most fibrotic area associated with tumor. D2-40 immunohistochemical staining was applied for fibrotic areas to detect the lymphatic spaces. Microlymphatic density, tumor stiffness, and clinicopathologic data were analyzed.RESULTS:
Higher elasticity value was associated with invasive size of tumor, microlymphatic density, histologic grade 3, absence of extensive intraductal component, presence of axillary lymph node metastasis, and Ki-67 labeling index (LI) in univariate regression analysis, and associated with Ki-67 LI and axillary lymph node metastasis in multivariate regression analysis. Microlymphatic density was associated histologic grade 3, mean elasticity value, and Ki-67 LI in univariate regression analysis. In multivariate regression analysis, microlymphatic density was correlated with mean elasticity value.CONCLUSION:
In breast cancer, tumor stiffness correlates with lymphangiogenesis and poor prognostic factors.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Mama
/
Neoplasias de la Mama
/
Análisis Multivariante
/
Análisis de Regresión
/
Linfangiogénesis
/
Diagnóstico por Imagen de Elasticidad
/
Ganglios Linfáticos
/
Metástasis Linfática
/
Invasividad Neoplásica
/
Estadificación de Neoplasias
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
Límite:
Adulto
/
Anciano
/
Aged80
/
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Yonsei Medical Journal
Año:
2016
Tipo del documento:
Artículo
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