Study on the Pharmaceutical Effect of Surfactants on the Sucralfate Capsule / 中国药房
China Pharmacy
; (12)2005.
Article
en Zh
| WPRIM
| ID: wpr-525436
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE:To study the effect of surfactants on the pharmaceutical index of sucralfate capsule and to opti?mize its dosage used in the formula.METHODS:The sucralfate capsule was prepared with different surfactants respectively.The disintegration,dissolution and dispersibility of the preparations were determined and their stripping curves were fitted with Weibull distribution model.Different surfactants and the effects of different dosages of which on the dissolution of su?cralfates were compared.RESULT:The sodium lauryl sulphate had the biggest promotion effect on the dissolution of sucral?fate.Optimal indexes of the capsule were achieved when the addition of sodium lauryl sulphate was2%.CONCLUSION:It is advisable to adopt2%sodium lauryl sulphate as the surfactants for the sucralfate capsule.
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Índice:
WPRIM
Idioma:
Zh
Revista:
China Pharmacy
Año:
2005
Tipo del documento:
Article