Expression of MMP-9 and TIMP-1 and Its Correlation with Lymph Node Metastasis in Esophageal Squamous Carcinoma / 中国医师杂志

ABSTRACT

Objective To study the expression of matrix metalloproteinase-9(MMP-9) and tissue inhibitor of metalloproteinase-1(TIMP-1), and its correlation with lymph node metastasis in esophageal squamous carcinoma(ESC). Methods The expressions of MMP-9 and TIMP-1 were detected in 78 cases of esophageal squamous carcinomas by using immunohistochemical SP method. Results The expression level of MMP-9 in high differentiated (grade Ⅰ～Ⅱ) and early stage (stageⅠ～Ⅱ) ESC was significantly lower than that in low differentiated(grade Ⅲ～Ⅳ) and late stage (stage Ⅲ～Ⅳ) ESC(P