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Simultaneous Determination of2Components in Compound Calcium Gluconate Oral Solution by HPLC / 中国药房
China Pharmacy ; (12)2005.
Artículo en Chino | WPRIM | ID: wpr-525640
ABSTRACT

OBJECTIVE:

To establish HPLC method for the simultaneous determination of calcium lactate and calcium gluconate in compound calcium gluconate oral solution.

METHODS:

The test was performed on C 18 column with column tem?perature at25℃;the mobile phase was composed of0.025mol/L NaH 2 PO 4 (pH=2.50)with a flow rate of1.0ml/min and sam ple size of20?l;the detection wavelength was210nm.

RESULTS:

The calibration curves were linear over the range of0.719~46.040mmol/L(r=0.9999)for lactic acid and0.315~20.160mmol/L(r=0.9999)for gluconic acid.The average recovery rates of which were99.0%(RSD=1.65%)and100.5%(RSD=1.36%),respectively.

CONCLUSION:

This method is fast,simple,accurate,and it can be employed directly without isolation to determine the content of calcium lactate and calcium glu?conate simultaneously and to control the quality of compound calcium gluconate oral solution as well.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: China Pharmacy Año: 2005 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: China Pharmacy Año: 2005 Tipo del documento: Artículo