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Inflammation and coagulation activation are associated with gallstone formation in golden hamsters / 中国病理生理杂志
Chinese Journal of Pathophysiology ; (12)1999.
Artículo en Chino | WPRIM | ID: wpr-525764
ABSTRACT

AIM:

To elucidate the relationship of inflammation, coagulation and cholesterol gallstone formation.

METHODS:

Hamsters were divided into four groups control group (feeding normal diet), lithogenic diet (LD) 2 weeks group, LD 6 weeks group and LD+aspirin 6 weeks group. Gallstone incidence, antithrombin antigen (AT-ⅢAg), antithrombin activity (AT-ⅢAc), thrombin (F-ⅡaAc), plasminogen activator inhibitor activity (PAIAc), plasmin activity (PlmAc), D-dimerAg and C-reactive protein (CRP) in gallbladder bile were observed as read-out parameters.

RESULTS:

The incidence of gallstones in control group, LD 2 weeks group, LD 6 weeks group and LD+aspirin group were 0%, 20%, 73% and 25%, respectively. AT-ⅢAg, F-ⅡaAc, D-dimer and CRP in LD 2 weeks group and LD 6 weeks group were significantly higher than those in the control group (P

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Journal of Pathophysiology Año: 1999 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Journal of Pathophysiology Año: 1999 Tipo del documento: Artículo