Inflammation and coagulation activation are associated with gallstone formation in golden hamsters / 中国病理生理杂志

ABSTRACT

AIM: To elucidate the relationship of inflammation, coagulation and cholesterol gallstone formation. METHODS: Hamsters were divided into four groups control group (feeding normal diet), lithogenic diet (LD) 2 weeks group, LD 6 weeks group and LD+aspirin 6 weeks group. Gallstone incidence, antithrombin antigen (AT-ⅢAg), antithrombin activity (AT-ⅢAc), thrombin (F-ⅡaAc), plasminogen activator inhibitor activity (PAIAc), plasmin activity (PlmAc), D-dimerAg and C-reactive protein (CRP) in gallbladder bile were observed as read-out parameters. RESULTS: The incidence of gallstones in control group, LD 2 weeks group, LD 6 weeks group and LD+aspirin group were 0%, 20%, 73% and 25%, respectively. AT-ⅢAg, F-ⅡaAc, D-dimer and CRP in LD 2 weeks group and LD 6 weeks group were significantly higher than those in the control group (P