Pentoxifylline Modified Release Capsules' Preparation and Its in Vitro Drug Release Characteristics / 中国药房

ABSTRACT

OBJECTIVE: To prepare pentoxifylline(PTX) modified release capsule and to investigate its in vitro drug release characteristics. METHODS: The orthogonal design was adopted to optimize the formula and the preparation technics; and the contents of PTX were determined by UV - spectrophotometry. RESULTS: The optimized formula and preparation technics were as follows PTX 200mg, hydroxy propyl methylcellulose 90mg, stearic acid 60mg, octadecyl alcohol 50mg, flu-idization for 25min at 80℃;PTX assumed linear relationship with absorbability at the range of 1.0-10.0?g /ml(r = 0.9 995), the average recovery was 101.24% , RSD = 1.27% (n = 6) . CONCLUSION: The optimized technics is simple and easy to handle; PTX modified release capsules prepared in the technics were of good stability and which have an obvious in vitro slow release property.