Expressions of COX-2 and VEGF in non-small cell lung cancer and the relationships between them and tumor angiogenesis / 中国医师杂志

ABSTRACT

Objective To investigate the expressions of Cycloxygenase-2(COX-2),vascular endothelial growth factor(VEGF) in non-small cell lung cancer(NSCLC) to explore the relationships between them and the tumor biological characteristics,tumor angiogenesis in NSCLC.Methods The expressions of COX-2,VEGF and the microvessel density(MVD) were detected by immunohistochemical staining.Results The positive rates of COX-2 and VEGF expression in NSCLC tissue were 55.5% and 66.7% respectively,with significantly higher than those of normal lung tissue(all P