Observation on Therapeutic Effect of Combined Use of Capreomycin in Treating 268 Patients with Multiple-drug-resistant Tuberculosis / 中国药房

ABSTRACT

OBJECTIVE:To observe the therapeutic effect of combined use of capreomycin in treating multiple-drug-resistant tuberculosis.METHODS:After 268 patients with multiple-drug-resistant tuberculosis had underwent intensive treatment with levofloxacin,pyrazinamide,pasiniazid,protioamide and capreomycin for 3 months,they underwent another 9 months of strengthened treatment with levofloxacin,pasiniazid,and rotioamide.RESULTS:The negative rate determined in sputum test for tuberculosis bacteria was up to 78.36%,and the closing rate of the cavity was up to 37.76%.CONCLUSION:The therapeutic effect for treatment of multiple-drug-resistant tuberculosis can be improved by carrying out the principle of whole range direct monitoring of chemotherapy and using capreomycin in combination with other drugs to increase the sensitivity to mycobacterium tuberculosis.