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Concentration Determination of Floxuridine in Serum and Organs of Mice by RP-HPLC / 中国药房
China Pharmacy ; (12)2005.
Artículo en Chino | WPRIM | ID: wpr-526253
ABSTRACT

OBJECTIVE:

To establish RP-HPLC method for the fast determination of floxuridinein in serum and homogenate of some of the organs of mice.

METHODS:

The determination was performed on C18 chromatographic column with its mobile phase consisted of phosphate buffer(pH= 7.4) - methanol(95∶5) and with its detection wavelength at 268nm.

RESULTS:

Linear detection concentration ranges of floxuridinein were all at 15~240?g/ml. The minimum detection concentration was 3?g/mL(S/N≥3). The average extraction recovery was above 95%. The average recovery ranged from 91%to 112%. Both the intra-day and inter-day precisions were less than 10%.

CONCLUSION:

The method is simple, rapid, reliable and economical, and it can be used for the determination of serum floxuridinein concentration and the study of its body distribution in animals.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: China Pharmacy Año: 2005 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: China Pharmacy Año: 2005 Tipo del documento: Artículo