Expression and significance of skp2 and C-myc protein in hepatocellular cancinoma / 中国普通外科杂志

ABSTRACT

Objective To investigate the expression of Skp2 and C-myc in hepatocellular carcinoma and its relationship with clinicopathologic characteristics.Methods The expression of skp2 and C-myc was evaluated in hepatocellular carcinoma tissues of 48 patients,liver cirrhosis tissues of 20 cases,and normal liver tissues of 16 patients by immunohistochemistry(PV9000 two steps methods).Results The expression rate of skp2(33.3%) in hepatocellular carcinoma tissues was significantly higher than that in liver cirrhosis tissues((negative) expression)(P=0.008)and normal liver tissues(negative expression)(P=0.020).The(expression) of skp2 was correlated with histological differentiation and metastasis(P﹤0.001 and P=(0.017)),but not with tumour size(P=0.058),and it was not expressed in highly differentiated(hepatocellular) carcinomas.The expression rate of C-myc protein in hepatocellular carcinoma tissues((58.3)%) was significantly higher than that in liver cirrhosis tissues(15%)(P=0.001) and normal tissues((negativ)e expression)(P