Clinical study of Lulutong injection(路路通注射液) on improving microcirculation after burns / 中国中西医结合急救杂志

ABSTRACT

Objective: To observe the effects of Lulutong injection on microcirculation disturbance after burns. Methods: Eighty-eight patients with mild burn were randomly divided into two groups. From the first day after burn, the treatment group received 500 mg Lulutong injection intravenously injected in 5% glucose, once a day for 14 days as a therapeutic course. The control group was treated with 5% glucose. No large amount of solution was infused because the burned patients were mild and no shock was found. Both groups were received anti-infection treatment using 0.6 g of clindamycin. The morphology of nail-fold microcirculation , the state around the nail-fold microcirculation, hemorrheological parameters, changes in coagulation function 3, 7 and 14 days after burn and the side effects of drugs were observed. Results: Compared to the control group, in the treatment group, the arterioles dilated more markedly, the blood flow of micro-vessels became faster, the flowing score of nail-fold microcirculation decreased obviously, the state around the nail-fold microcirculation changed significantly, the total score declined faster, but no obvious changes were found in erythrocyte aggregation index, the number of leukocyte adhesion and coagulation function . There were 2 cases with dizziness. Conclusion: Lulutong injection may improve the microcirculation in patients with burn, and has little side effect.