Preparation of Tretinoin Liposome by Calcium Acetate Gradient Method / 中国药房
China Pharmacy
;
(12)2001.
Artículo
en Chino
| WPRIM
| ID: wpr-527707
ABSTRACT
OBJECTIVE:
To evaluate the feasibility of preparing tretinoin liposome by calcium acetate gradient method and to compare this method with the microfilm and the antiphase evaporation method.METHODS:
Tretinoin liposome was pre-pared by microfilm method,antiphase evaporation method and calcium acetate gradient method,respectively.Sephadex G-50was used for isolation and ultraviolet spectrophotometry was utilized to determine the entrapped efficiency and grain size of liposomal tretinoin.Electronmicroscope was applied to observe the shape of tretinoin liposome.RESULTS:
The calcium ac-etate gradient technology achieved the highest entrapped efficiency of90.48%.The liposomes had perfect shape with the mean diameter of35.8nm and kept stable in quality at4℃for3months.CONCLUSION:
The liposome with high entrapped effi-ciency could be prepared by calcium acetate gradient method,and the method is feasible.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacy
Año:
2001
Tipo del documento:
Artículo
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