Administration of antibiotics in the treatment of infection of burns based on bacteriological surveillance from burn wound and the analysis of bacterial resistance to antibiotics / 中国医师杂志

ABSTRACT

Objective To investigate the administration of antibiotics in the treatment of infection of burns based on bacteriological surveillance from burn wound.Methods A retrospective analysis of bacterial culture and drug-sensitivity results from burn wound and subeschar tissues in 581 patients during 1999 to 2004 was carried out.Results Eight hundred and eighty-seven strains of bacteria were isolated from burn wound and subeschar tissues in 581 patients,among which 481 strains were gram negative(54.23%),and 406 strains were gram positive(45.77%).Among the bacteria of gram negative,the most majority was Pseudomonas and then was the Enterobacteriaceae.Among the bacteria of gram positive,Staphylcoccus aureus was the majority,and MRSA accounted for 71.48% in the Staphylcoccus aureus.The resistance of Pseudomonas to Netilmicin was decreased from 20.1% to 4.9%,and the resistance of Enterobacteriaceae to Imipenem was still in a low level.All bacteria of gram positive were sensitive to Vancomycin.Conclusion The majority of the bacteria of burn infection is gram negative.The isolated bacteria show multiple resistance to antibiotic.The analysis of bacteria from burn wound and resistance of bacteria to antibiotic is very important to experiential treatment of antibiotic for burn infection.