Experimental study of early gestation termination induced by low frequency ultrasound / 中国医师杂志

ABSTRACT

Objective To investigate the availability of early gestation termination with low frequency ultrasound.Methods The 10th day rabbit embryos were irradiated with low frequency focused ultrasound of 6 different levels of sound intensity.The rates of embryonic mortality were observed and the expression of p53 was detected by using immunohistochemistry 10 days after the irradiating.Results The rates of embryonic mortalities were 25.00%,72.88 % and 100% with the intensity of 30 W/cm~2,35 W/cm~2 and 40 W/cm~2 for 60 seconds,respectively.The expression of p53 in placenta cells increased after irradiating,peaked at 96 hours,and recovered to control level at 192 hours.Conclusion It is feasible for early pregnancy termination with low frequency ultrasound.The low frequency ultrasound may induce the increased expression of p53 in placenta cells,but the expression may be recovered.