Expression of telomerase inhibitor Pinx1 in leukemia cells and its correlation with telomerase activity / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)1999.
Artículo
en Chino
| WPRIM
| ID: wpr-528486
ABSTRACT
AIM:
To study the expression of telomerase inhibitor Pinx1 in acute leukemia cells and during the differentiation of acute promyelocytic leukemia cells, and to realize its effect on telomerase activity.METHODS:
Realtime quantitative PCR with fluorescence probe hybridization was used to measure the expression of Pinx1 and hTERT mRNA in acute leukemia cells and during differentiation of NB4 cells induced by ATRA. The correlations between Pinx1 and hTERT expression were also analyzed.RESULTS:
Pinx1 mRNA expression in acute leukemia samples (0.00312, 5.42?10 -4-0.024) was significantly higher than that in normal bone marrow mononuclear cells (7.89?10 -4, 0-0.00863, P
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Pathophysiology
Año:
1999
Tipo del documento:
Artículo
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