The role of multi-drug resistance related proteins in hepatocellular carcinoma multidrug resistance cell line HePG2/ADM / 中国普通外科杂志
Chinese Journal of General Surgery
; (12)2000.
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en Zh
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| ID: wpr-528693
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WPRO
ABSTRACT
0. 05). At the protein level, the expressions of MDR1, BCRP and LRP in HePG2/ADM were significantly higher than HePG2 and L02 ( FMDR1= 28. 68, FBCRP= 18. 60, FLRP= 6. 28, P 0. 05). Conclusion The four genes are probably the normally expressed genes in the liver. The expression of MDR1 and BCRP could be up-regulated by anticancer agents in vitro. MDR1 and BCRP may play very important roles in the MDR of HePG2/ADM. However, MRP1 and LRP may have no relations with the multi-drug resistance of HePG2/ ADM cell lines.
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Zh
Revista:
Chinese Journal of General Surgery
Año:
2000
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Article