Impact of Allopurinol on Heart Function,Endothelial Function and Indexes of Inflammation in Patients with Acute Myocardial Infarction / 中国药房

ABSTRACT

OBJECTIVE:To observe the impact of allopurinol on heart function,endothelial function and indexes of inflammation in controlling hyperuricemia in patients with acute myocardial infarction(AMI).METHODS:A total of 98 patients with AMI complicated with hyperuricemia were randomized to treatment group(treated with allopurinol plus alimentary control)and control group(alimentary control alone)for 6wk.Heart function,endothelial function and inflammation indexes between 2 groups before and after treatment were observed.RESULTS:In treatment group,serum uric acid level were decreased significantly(t=2.317,P=0.046),LVEF and flow-mediated dilatation(FMD)function improved significantly(t=— 2.106,P=0.073;t=— 3.47,P=0.007),and C reactive protein level were significantly lower than in the control group(t=4.78,P=0.002).CONCLUSION:Allopurinol can decrease hyperuricemia level,improve endothelial dysfunction,heart function and inflammatory reactions.