Optimization of the Formula of Puerarin Derivative Nanoparticles by Central Composite Design / 中国药房
China Pharmacy
;
(12)1991.
Artículo
en Chino
| WPRIM
| ID: wpr-528842
ABSTRACT
OBJECTIVE:
To optimize the formula technology of puerarin derivative 4ac-loaded nanoparticles by central composite design.METHODS:
4ac nanoparticles were prepared using solvent evaporation method, with mean diameter, encapsulation rate and yield as dependent variables, multi-linear regression and binomial fit were performed on the 3 independent variables at different leveldosages of supporter lactic acid/ glycolic acid copolymer and surfactant polyvinyl alcohol, and the diameter of pinhole. The optimum experimental conditions were predicted by response surface method.RESULTS:
The binomial fitting equations of indexes were all superior to their multi-linear regression equations, and the predictive values in the established mathematical model were in good conformity with the experimental values.CONCLUSION:
Central composite design plus response surface method shows a good predictability in optimizing the formula technology of 4ac-loaded nanoparticles.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio pronóstico
Idioma:
Chino
Revista:
China Pharmacy
Año:
1991
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS