Effect of the Hematostatic Components Total Iridoid Glycosides of Habra Lamiophlomis Rotata on Rats'Blood Conglomeration Parameters / 中国药房

ABSTRACT

OBJECTIVE:To study the effect of the hematostatic effective components of Herba Lamiophlomis rotata on rat’s blood conglomeration parameters.The toxicity of these components was simultaneously studied.METHODS:Herba Lamiophlomis rotata water extract (HLRE)(3g?kg-1),Total Flavonoids(P1,0.36g?kg-1),Total Iridoid Glycosides(P2,0.99g ?kg-1),Maximus Polarity Components(P3,1.65g?kg-1)and normal sodium NS were given orally in rats for 14 days.Blood samples were collected from common carotid artery;prothrombin time (PT),activated partial thromboplastin time (APTT),thrombin time (TT)and fibrinogen (FIB)were tested.Different oral doses of(P2 ,1.4,0.7,0.35 g?kg-1)and Yunnan white powder (BY,0.9g?kg-1)were given to rats and conglomeration parameters were determined too.The maximum tolerable dose (MTD)and LD50 of mice were determined after different doses of P2 were given with oral administration and intraperitoneal injection.RESULTS:Compared to NS control group,each composition of Lamiophlomis rotata Kudo can shorten the TT by 18.59%、—3.12%、24.11%and 9.92%respectively,and increase the content of FIB by 25.32%、8.67%、28.29%and 5.36%respectively.There was obvious change in HLRE and P2(P