Inhibitory Effect of Mifepristone-releasing Implants on Endometriosis in Rats / 中国药房
China Pharmacy
; (12)1991.
Article
en Zh
| WPRIM
| ID: wpr-529994
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE:To observe the efficacy of mifepristone-releasing implants for endometriosis in rats.METHODS:Mifepristone-releasing implants(one tube at 0.75,1.5,and 3.0 cm in length,or 2,3,4 tubes at 3 cm in length) were embedded subcutaneously in model rats with endometriosis.The inhibition ratio on the endometriosis was measured 3 months later and compared with the placebo control group.RESULTS:In vitro mean drug release rate of about 9 ?g?d-1 was achieved for the one-tube implant at 3 cm in length for the first 15 days,but reduced to 5 ?g?d-1 after 30 days and which was maintained for over 6 months.Inhibition ratios of(18.6?17.3)%,(31.5?12.7)% and(72.2?12.3)% on the growth of endometrial explants were achieved after subcutaneous implantation of mifepristone-releasing implants(1 tube at 1.5 cm or 3 cm in length or 2 tubes at 3.0 cm in length),showing significance differences as compared with control group(P
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Índice:
WPRIM
Tipo de estudio:
Clinical_trials
Idioma:
Zh
Revista:
China Pharmacy
Año:
1991
Tipo del documento:
Article