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Investigation of Dissolution of DEHP in Packaged Infusion Sets of Paclitaxel Injection / 中国药房
China Pharmacy ; (12)2001.
Artículo en Chino | WPRIM | ID: wpr-530255
ABSTRACT

OBJECTIVE:

To investigate the dissolution of DEHP in PVC infusion set and the packaged infusion sets of the Paclitaxel injection so as to evaluate the safety of clinical infusion sets for paclitaxel.

METHODS:

The packaged infusion sets of Paclitaxel injection were collected from 9 Three-A grade hospitals in Chongqing.Paclitaxel injections were prepared as per actual concentration needed by the clinic and dripped through eight different infusion sets(in which 7 were packaged infusion sets) for 3 h.The peak area of the collected solution was measured and its content was determined by HPLC,and the effect of infusion time on the dissolution of DEHP was investigated as well.

RESULTS:

The dissolution of DEHP dripped through eight infusion sets were 1 408,9 393,6 576.5,2 412.6,8 194.4,0,8 477.2,and 8 037.4 ?g,respectively.The dissolution increased with the prolonging of infusion time.

CONCLUSION:

At present,the majority of packaged infusion sets of Paclitaxel injection were made form PVC materials.The safe medication of Paclitaxel can't be ensured for the dissolved DEHP can enter the blood directly,thus its hazardness should be given great attention.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: China Pharmacy Año: 2001 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: China Pharmacy Año: 2001 Tipo del documento: Artículo