Effects of Yigu capsule on the level of cbf ?-1 mRNA in bone of ovariectomized osteoporosis rats / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)1986.
Artículo
en Chino
| WPRIM
| ID: wpr-530312
ABSTRACT
AIM:
To analyze the regulatory effect of Yigu capsule on core binding factor alpha 1 (cbf ?-1) gene expression in bone of ovariectomized osteoporosis (OP) rats.METHODS:
Thirty-six 10-month old Sprague-Dawley female rats were randomized into three groups sham-operated group, model group and drug group. After intervention by the corresponding methods, the femurs were collected, SYBR green Ⅰ fluorescence quantitative PCR technique was applied with the internal control of GAPDH according to the relative quantitative formula (2-Ct), the differentially expressed multiples between the model group or drug group and sham-operated group were calculated.RESULTS:
Quantitative formula analysis showed that the level of cbf ?-1 gene expression in bone of model groups was decreased than that in sham-operated rats [compared with sham-operated group, P0.05).CONCLUSION:
The results of this study show that cbf ?-1 gene expression in bone tissue of ovariectomized OP rat is decreased, and Yigu capsule increases the level of cbf ?-1 gene expression in bone of OP, indicating that Yigu capsule induces bone marrow mesenchymal stem cells into osteoblasts.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio pronóstico
Idioma:
Chino
Revista:
Chinese Journal of Pathophysiology
Año:
1986
Tipo del documento:
Artículo
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