Changes in TCR V? subfamily nave T cells in peripheral blood of patients with multiple myeloma / 中国病理生理杂志
Chinese Journal of Pathophysiology
; (12)1989.
Article
en Zh
| WPRIM
| ID: wpr-530504
Biblioteca responsable:
WPRO
ABSTRACT
AIM:To detect the existence of signal joint T-cell receptor excision DNA circles(sjTRECs)of 23 TCR V? subfamilies in mononuclear cells of patients with multiple myeloma(MM),and to evaluate the recent thymic emigrants of corresponding V? subfamily nave T cells in MM patients.METHODS:23 TCR V? subfamily sjTRECs were amplified in genomic DNA from 5?104 PBMCs of 12 cases in MM patients by using semi-nest PCR.10 normal individuals served as controls.RESULTS:The number of detectable V? subfamily sjTRECs was 5.00?2.45 from MM patients,as compared with 9.60?5.48 from normal individuals,the difference was significant(P
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Pathophysiology
Año:
1989
Tipo del documento:
Article