Clinical Observation of Entecavir in Treatment of Patients with Chronic Severe Hepatitis B / 中国慢性病预防与控制

ABSTRACT

Objective To evaluate the efficacy and safety of entecavir(ETV)treatment on patients with chronic severe hepatitis B.Methods 82 native patients of chronic severe hepatitis B with positive HBV-DNA were divided into two groups,treatment group(37 cases) were prescribed with normal treatment plus ETV(0.5mg qd),while control group(45 cases) were treated with normal treatment alone.Symptoms,the levels of TB,ALT,PTA,HBV-DNA loads were determined before and at the end of the study.Results The effective rate of the treatment group(75.7%) were significant higher than that in the control group(53.4%)(P