Protective Effect of Captopril on Nicotine-induced Endothelial Dysfunction in Rats / 中国药房
China Pharmacy
;
(12)2007.
Artículo
en Chino
| WPRIM
| ID: wpr-531092
ABSTRACT
OBJECTIVE:
To discuss the protective effect of captopril on the nicotine-induced impairment of endothelium-dependent relaxation(EDR) in rat mesenteric arteries and explore the possible mechanisms underlying the observed protective effects of captopril.METHODS:
A total of 30 rats were randomly divided into 3 groups normal control group,nicotine group(2 mg?kg-1),captopril group(nicotine 2 mg?kg-1+captopril 3 mg?kg-1).After treatment for 4 weeks,vasodilatation rate of mesenteric arteries,the content of NO and NOS,and the SOD activities in serum were measured.RESULTS:
Nicotine significantly decreased the vasodilatation rate of mesenteric arteries and decreased the content of NO and NOS,SOD activities in serum(P
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacy
Año:
2007
Tipo del documento:
Artículo
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