Analysis of Correlation Factors on Methotrexate(MTX)Concentration in Children with Acute Lymphoblastic Leukemia / 中国药房

ABSTRACT

OBJECTIVE:To study the correlation between MTX concentration and hydration volume,alkalization volume,urine volume,body weight and biochemical indexes in Children with acute lymphoblastic leukemia(ALL).METHODS:The case histories of pediatric ALL patients hospitalized between 2003 and 2006 who were treated with MTX antitumor thrapy were reviewed retrospectively for a recording of MTX concentration,hydration volume,alkalization volume,urine volume,body weight and biochemical indexes etc.The data were analyzed with multiple linear regression method by SPSS(10.0)software.RESULTS:No significant correlation was noted between log MTX concentration and most of the biochemical indexes,hydration volume,alkalization volume and urine volume;however,log MTX concentration at 24 h was negatively correlated with body weight but positively correlated with TBIL(total bilirubin)(P