Literature Review of Allopurinol and Analysis of Allopurinol-induced Adverse Reactions / 中国药房
China Pharmacy
; (12)2007.
Article
en Zh
| WPRIM
| ID: wpr-533004
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE:To probe into the tendency,characteristics and correlation factors of the allopurinol-induced adverse drug reactions(ADR). METHODS: The literature related to allopurinol-induced ADR retrieved from CNKI (between 1991 and 2008) as well as the allopurinol-induced clinical ADR cases collected in our hospital were summarized,analyzed and compared. RESULTS: A total of 77 ADR cases(reported in 76 papers) met the diagnostic criteria of ADR specified by Ministry of Public Health were collected,of which,10 cases(12.99%) died. A total of 67 clinical cases were collected from our hospital,of which,2 cases(2.99%) died,showing a high mortality rate. Mucocutaneous lesion was the chief ADR type,accounting for more than 90%,and the ADR chiefly appeared as drug rash and febrile and multiple organs or systems were often involved in the ADR. CONCLUSION: It is important to enhance ADR monitoring in clinical use of allopurinol.
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WPRIM
Idioma:
Zh
Revista:
China Pharmacy
Año:
2007
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Article